纤维素-制药辅料瑞典爱尔兰直播 //www.knowyourgadget.com 2021年6月9日星期三10:04:43 +0000 en - us 每小时 1 https://wordpress.org/?v=5.7.2 利用纳米晶悬浮液研制亚微克剂量微片的新方法 //www.knowyourgadget.com/news/nanocrystalline-suspension-low-dose-micro-tablet/ 菲利普 2021年6月9日星期三09:30:55 +0000 新闻 纤维素 excpients //www.knowyourgadget.com/?p=227490 < div风格= " margin-bottom: 20 px;" > < img宽度= " 1920 "高度= " 1080 " src = " //www.knowyourgadget.com/wp-content/uploads/2021/06/A-Novel-Use-of-Nanocrystalline-Suspensions-to-Develop-Sub-Microgram-Dose-Micro-Tablets.png "类=“attachment-post-thumbnail size-post-thumbnail wp-post-image“alt = "小说使用纳米晶体悬浮液开发Sub-Microgram剂量微片剂" loading="lazy" srcset="//www.knowyourgadget.com/wp-content/uploads/2021/06/A-Novel-Use-of-Nanocrystalline-Suspensions-to-Develop-Sub-Microgram-Dose-Micro-Tablets.png 1920w,//www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 300 x169.png 300 w, //www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 1024 x576.png 1024 w,//www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 150 x84.png 150 w, //www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 768 x432.png 768 w,//www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 1536 x864.png 1536 w,//www.knowyourgadget.com/wp-content/uploads/2021/06/A-Novel-Use-of-Nanocrystalline-Suspensions-to-Develop-Sub-Microgram-Dose-Micro-Tablets-600x338.png 600w" size ="(max-width: 2020px) 100vw, 2020px " /> >< p>开发低剂量的固体口服药品是一项挑战;当片剂尺寸从传统的片剂减小到微/迷你片剂(直径1.2 - 3mm)时,这一挑战进一步加剧。为了缓解CU的问题,我们提出一个新的使用纳米晶体悬浮结合高剪切湿造粒(& # 8230;)< / p > < p > Der Beitrag < rel =“nofollow”href = " //www.knowyourgadget.com/news/nanocrystalline-suspension-low-dose-micro-tablet/ " >小说使用纳米晶体悬浮液开发Sub-Microgram剂量Micro-Tablets < / > erschien先 Pharma Excipients.

< div风格= " margin-bottom: 20 px;" > < img宽度= " 1920 "高度= " 1080 " src = " //www.knowyourgadget.com/wp-content/uploads/2021/06/A-Novel-Use-of-Nanocrystalline-Suspensions-to-Develop-Sub-Microgram-Dose-Micro-Tablets.png "类=“attachment-post-thumbnail size-post-thumbnail wp-post-image“alt = "小说使用纳米晶体悬浮液开发Sub-Microgram剂量微片剂" loading="lazy" srcset="//www.knowyourgadget.com/wp-content/uploads/2021/06/A-Novel-Use-of-Nanocrystalline-Suspensions-to-Develop-Sub-Microgram-Dose-Micro-Tablets.png 1920w,//www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 300 x169.png 300 w, //www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 1024 x576.png 1024 w,//www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 150 x84.png 150 w, //www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 768 x432.png 768 w,//www.knowyourgadget.com/wp - content/uploads/2021/06/a小说- - -纳米晶体悬浮体的使用开发-子微克-微-平板电脑- 1536 x864.png 1536 w,//www.knowyourgadget.com/wp - content/uploads/2021/06/a小说-使用- -纳米晶体的悬浊液-发展-子微克-微-平板电脑- 600 x338.png 600 w "大小= " (max-width:

开发低剂量的良好含量均匀性(CU)固体口服药物具有挑战性;当片剂尺寸从传统的片剂减小到微/迷你片剂(直径1.2 - 3mm)时,这一挑战进一步加剧。为了缓解CU问题,我们首次提出了一种结合高剪切湿造粒的纳米晶悬浮液的新用途。

In this approach, nanomilled drug in the form of nanocrystalline suspension is sprayed onto the powder bed to ensure uniform distribution. The resulting granules had adequate particle size distribution and flow characteristics to enable manufacturing of micro-tablets with good weight uniformity and tensile strength. Nanomilled drug resulted in excellent content uniformity among individual micro-tablets even at a dose strength as low as 0.16 mcg, whereas micronized drug resulted in unacceptable CU even at 5x higher dose strength (0.8 mcg).

Besides, the use of nanomilled drug has enhanced the dosing flexibility of micro-tablets and showed superior dissolution performance in comparison with micronized drug with no impact of storage conditions (40°C/75 %RH for six months) on their dissolution performance. The proposed approach is simple and can be easily incorporated into traditional high shear wet granulation process to develop sub-microgram dose solid oral drug products. Continue on A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets

Article information: Saikishore Meruva, Prajwal Thool, Yuchuan Gong, Anjali Agrawal, Shyam Karki, William Bowen, Biplob Mitra, Sumit Kumar. A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets, Journal of Pharmaceutical Sciences, 2021. https://doi.org/10.1016/j.xphs.2021.05.025.

Der Beitrag A Novel Use of Nanocrystalline Suspensions to Develop Sub-Microgram Dose Micro-Tablets erschien zuerst auf Pharma Excipients.