利用纳米系统提高姜黄素的抗癌效果

姜黄素(Cur)是一种酚类化合物,可为人类食用安全。它表现出化学预防性,抗增殖,抗血管生成和抗致锑效果。然而,由于亲脂性质,新陈代谢,低生物利用度和快速消除分子,这些益处可能会受到阻碍。

Considering this, the present work reviews the use of CUR-based nanosystems as anticancer agents, including conventional nanosystems (i.e., liposomes, nanoemulsions, nanocrystals, nanosuspensions, polymeric nanoparticles) and nanosystems that respond to external stimuli (i.e., magnetic nanoparticles and photodynamic therapy). Previous studies showed that the effects of CUR were improved when loaded into nanosystems as compared to the free compound, as well as synergist effects when it is co-administrated alongside with other molecules.

为了最大限度地提高CUR的有益健康影响,需要严格控制关键因素,例如粒度,形态,以及包封材料和Cur之间的相互作用。此外,还有一个研究领域,在开发基于CU的纳米医疗应用中的开发中。2021欧洲杯竞猜软件Cur基纳米系统的成像引导的药物递送也可以直接靶向特异性细胞,从而增加该通用化合物的治疗和化学预防效果。

将完整的文章作为PDF下载到这里在这里阅读

文章信息:Araya-Sibaja,A. M .;salazar-lópez,n。j .;Wilhelm Romero,K .;Vega-Baudrit,J.R .;Domínguez-Avila,J.A .;Velázquezcontreras,C. a。Robles-Zepeda,R. e ;;Navarro-Hoyos,M。;González-aguilar,G.A。贝尔斯坦J. Nanotechnol。2021,12,1047–1062. 内政部:10.3762/bjnano.12.78

你可能还喜欢